Adapalene and Benzoyl Peroxide

What is Adapalene and Benzoyl Peroxide?

Adapalene is a gel that is used to treat acne vulgaris (pimples). The specific mechanism of action has yet to be discovered. When adapalene is applied to the skin, scientists believe it inhibits the development of skin cells, reducing the creation of pimples.

Acne is treated with benzoyl peroxide, a topical treatment (pimples). It destroys the acne-causing bacteria Propionibacterium acnes and encourages the formation of new skin cells. It also causes the skin to become dry. Increased cell development causes the pimple-infested skin to be replaced with fresh skin.


This medicine is used to treat acne on the skin. Adapalene (a retinoid) and benzoyl peroxide are used in this medicine (an antibiotic and skin-peeling agent). This product may help reduce the quantity and severity of acne pimples and speed up the healing process for those that do occur. Adapalene acts by slowing down cell development and reducing edema and inflammation. Benzoyl peroxide reduces the quantity of acne-causing germs while also drying up and peeling the skin.

Side Effects:

During the first four weeks of taking this product, you may experience skin redness, dryness, peeling, moderate burning, swelling, or acne worsening. 

Remember that your doctor recommended this medicine because they believe your benefit justifies the risk of adverse effects. The majority of people who use this medicine do not have any significant adverse effects.

However, if you detect any symptoms of significant allergic response, seek medical help right once.


If you are allergic to adapalene or benzoyl peroxide or vitamin A-related medicines (other retinoids such as isotretinoin), or if you have any other allergies, inform your doctor or pharmacist before taking this product. Inactive ingredients in this product may cause allergic reactions or other issues. Speak with your pharmacist for further information.

Tell your doctor or pharmacist about your medical history before using this medicine, especially if you have any of the following: other skin problems (such as eczema).

This medication can bleach hair or colored fabrics (such as clothing, bedding, and towels). When applying along with the hairline, dressing, and picking towel and bed sheet colors, use caution (if leaving on the skin overnight).

This medicine may make you more sensitive to the sun. Probably have spent a little time in the sun as possible. Tanning salons and sunlamps should be avoided. Wear sunscreen and protective clothing when you’re outside. If you get burnt or see blisters or redness on your skin, call your doctor straight once. Before using this lotion, make sure your skin has fully healed from a sunburn. Extremes of weather, such as wind or cold, can irritate the skin.

While using this treatment, avoid electrolysis, waxing, and chemical depilatories on the treated regions. Women who may become pregnant should avoid using this medicine since it is absorbed through the skin and may damage an unborn baby.

Inform your doctor if you are pregnant or plan to get pregnant. While taking adapalene, you should avoid getting pregnant. Adapalene has the potential to damage an unborn child. If you get pregnant while taking this medicine, talk to your doctor straight away about the risks and benefits.

When this medication is applied to the skin, it is unknown if it goes into breast milk. Consult your doctor before starting to breastfeed.


Medicine interactions might cause your medications to operate differently or put you at risk for significant adverse effects. This list does not cover all possible drug interactions. Keep a list of everything you use (including prescription and nonprescription medicines, as well as herbal items) and discuss it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medications without consulting your doctor.

Other medications that may enhance your sensitivity to sunlight (such as tetracyclines, thiazide water pills like hydrochlorothiazide, sulfa pharmaceuticals like sulfamethoxazole, quinolone antibiotics like ciprofloxacin), and other acne skin treatments may interact with this drug (such as tretinoin, dapsone).

Other harsh, irritating, or drying skin products should be avoided in the treated region. Hair perming solutions, alcohol/lime/menthol-containing products (such as astringents, toners, and shaving cream), medicinal or abrasive soaps or cleansers, soaps and cosmetics with a significant drying effect (such as alpha-hydroxy acids, glycolic acid), and drugs are all examples of these products.

Use this product with caution if you have recently used sulphur, resorcinol, or salicylic acid-containing treatments. Before applying this product, wait until the effects of such products on the skin have subsided.


Missed Dose

Every day, take your next dose at the same time. Do not increase the dosage without consultation with the doctor.


If this medicine is swallowed, it may cause damage. 

Cosmetics may be used; however, skin must be completely cleaned before the medicine is applied.

Some cosmetics and soaps can worsen acne. Moisturizers are potentially safe to use. Look for the words “non-comedogenic” or “non-acnegenic” on the label of cosmetics, moisturizers, and other skincare products. These items are unlikely to worsen your acne. To find out which products are safe to use, see your doctor or pharmacist. Acne isn’t caused by dirt, so keep that in mind. Cleaning your skin too frequently or too aggressively might irritate it and worsen acne.


At room temperature, keep firmly closed. Do not allow yourself to get frozen. All medicines should be kept out of reach of children and pets.

Do not flush or drop medications down the toilet or into a drain unless otherwise advised. Dispose of this product appropriately after it has expired or is no longer needed. For additional information on how to securely dispose of your product, contact your pharmacist or a local trash disposal business.

Manufacturing and Supply Contact of Adapalene and Benzoyl Peroxide:

A.S Lifesciences, located in India, is a pharmaceutical, nutraceutical, and cosmetics company. It is also one of India’s premier dermatological firms. We provide to third-party Pharma enterprises, sales firms, and Pharma experts, among other things, as part of its primary focus on producing excellent outcomes and ensuring client pleasure. Examples include tablets, capsules, and topical preparations such as creams, lotions, gels, moisturizers, serums, and oils.

A.S Lifesciences offers a completely integrated Third-party liability manufacturing & producing solvents service, from customized product formulations and product manufacture to label layout, package design, and private design solutions. Our derma manufacturing firm is India’s largest, providing the highest quality products, thanks to automated production capabilities and cutting-edge technology.


Q.1) What other drugs will affect the topical Adapalene and Benzoyl Peroxide?

Other drugs you take orally or inject are unlikely to interact with adapalene and benzoyl peroxide when applied topically. Many medications, however, can interact with one another. All drugs you use, including prescription and over-the-counter medications, vitamins, and herbal items, should be disclosed to each of your health care providers.

Q.2) Are Adapalene and Benzoyl Peroxide safe to use while pregnant or breastfeeding?

It is safe to use because adapalene is absorbed in very tiny amounts through the skin and into the body. 

Q.3) What are the side effects of Adapalene and Benzoyl Peroxide?

The most common side effects of adapalene and benzoyl peroxide are:

Adapalene side effects

Adapalene side effectsBenzoyl peroxide side effects
IrritationContact dermatitis
Flares for acneSkin dryness

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